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Ginger Health Benefits



1.  Painkiller

Ginger effectively reduces subjective pain reports .
2 grams day of ginger may modestly reduce muscle pain from resistance exercise and prolonged running, particularly if taken for a minimum of 5 days.
Ginger is as effective as diclofenac (an NSAID pain medication) for pain management, without leading to digestive discomfort .

2.  Menstrual Cramps

Ginger is more effective in reducing pain severity than placebo. In addition, ginger appears to be as effective as mefenamic acid (an NSAID pain medication) .

3.  Osteoarthritis

Some research shows that ginger improves the effect of osteoarthritis, while other studies show that ginger is only effective during the first treatment so it more research is necessary to determine the true effectivity .

4.  Allergy and Asthma

Ginger is better for people with Th2 dominance.
Zerumbone, an active ingredient in ginger, enhances the Th1 response and helps with Th2 allergic response to egg white protein (albumin) in mice .
Ginger helps with asthma by suppressing Th2-mediated immune response in mice .
Ginger reduce smooth muscle contraction in the airway by reducing acetylcholine-induced contraction.

5. Eczema

6-Shogaol, a compound found in ginger, alleviates allergic dermatitis (eczema) in mice via cytokine inhibition by activating the Nrf2 pathway .
Eczema is Th2 dominant condition, so it make sense that ginger helps.

Ginger Aids Digestion

6.  Gut and Digestion

Ginger increased prostaglandins in the stomach lining (while NSAIDs decrease) in osteoarthritis patients who develop stomach problems from long term NSAID use .
Animal studies confirm that ginger reduces stomach lesions, possibly by inhibiting growth of Helicobacter pylori and through reducing stomach acid secretion .

7. Nausea and Vomiting

Ginger prevents overactivation of the vagal nerve that triggers nausea and vomiting by inhibiting serotonin function in the digestive tract .
Ginger is an effective non-drug relief for morning sickness during early pregnancy .
Ginger helps with nausea and vomiting as side effects of medications, including chemotherapy .

8. Stomach Discomfort

Ginger stimulates gut flow (peristalsis). However, the exact effects of ginger vary depending on different species of mammals .
Ginger accelerates stomach emptying into the small intestines in healthy people, so it can help in the case of overeating or indigestion .
A small randomized, double-blind, placebo-controlled trial shows that ginger can help with digestive symptoms in people who frequently have upset stomach (functional dyspepsia) .
Ginger does not affect gallbladder movements .
Ginger can regulate bowel transit in rats with irritable bowel syndrome .

Liver Detoxification

9. Protects the Liver

Supplementation with ginger, together with alpha-lipoic acid, help slow down age-related structural changes in old rats .
Ginger can help protect tuberculosis patients from liver toxicity due to antituberculosis drugs .
Ginger protects the kidney and liver against cadmium toxicity in rabbits poisoned with cadmium .
Ginger protects against aluminum toxicity in rats .

10.  Oxidative Stress

Ginger contains many potent antioxidants .
6-shogaol activates Nrf2, thus protects against oxidative stress .
Ginger is an effective antioxidant as part of an anti-tuberculosis therapy.

Ginger Has Anti-Cancer Effects

Several active compounds in ginger are potent against the hallmarks of cancer.

11. Can Induce Cancer Cells Death by Apoptosis

Ginger terpenoids can induce apoptosis in endometrial cancer cells through p53 activation.
Zerumbone, an ingredient in ginger, can induce apoptosis in pancreatic cancer cells through the p53 signal pathway .

12. Can Sensitize Cancer Cells to Radiation

Zerumbone can sensitize colorectal cancer cells to radiation, making radiation therapy more effective.

13. Inhibit Cancer Cell Growth

6-gingerol can inhibit growth of liver (hepatoma) and bone (osteosarcoma) cancer cells .

14. Stops New Blood Vessels that Allows Cancer Cells to Grow

Cancer cells develop the ability to grow new blood vessels called angiogenesis. Ginger inhibits angiogenesis in skin cancer.  
Zerumbone inhibits angiogenesis by blocking NF-κB in stomach, pancreatic, ovarian, and colon cancer in cell-based studies .
Administration of 6-gingerol to mice injected with melanoma cells inhibits pathways necessary for angiogenesis, including VEGF and bFGF .


15. Ginger Protects DNA

Ginger essential oil has been found to reduce DNA damage from mold toxin called aflatoxin B1 .
Ginger can help protect sperm DNA against oxidative stress, suggesting that it can help improve fertility in men .

16. Ginger Inhibits Cancer Cell Migration

6-Gingerol inhibits metastasis (cell migration) of breast cancer cells in a cell study .

Ginger Helps with Cardiovascular Risks

17. Ginger Improves Blood Cholesterol/Triglyceride  Profile

Ginger improves blood CRP, blood sugar markers, and cholesterol/triglyceride profiles in human subjects.
Ginger can lower blood pressure by modulating the nervous system via stimulation of muscarinic receptors and blockade of calcium channels .

18. Prevent Hardening of the Arteries

6-Gingerol can protect cells that line the blood vessels from oxidative stress, suggesting that it might help prevent hardening of the arteries .

Ginger Helps with Metabolic Health

19. Ginger Improves Blood Sugar Levels


Ginger reduces fasting blood glucose and HbA1c in humans .

20. Helps with Non-Alcoholic Fatty Liver Disease

12 weeks of supplementation with two grams of ginger daily significantly reduced several liver enzymes, inflammatory cytokines, and insulin resistance index compared to placebo .
Ginger essential oil protects the liver against non-alcoholic fatty liver disease and related metabolic diseases induced by high-fat diet in obese mice.
Treatment with ginger helps reduce fructose-induced fatty liver and high triglyceride levels in rats by acting through the liver’s carbohydrate sensor.

21. Ginger Can Mitigate Obesity from a Poor Diet

Ginger can keep mice on a high fat diet from getting obese and improved exercise endurance capacity by activating the PPARδ pathway.

Ginger is an Antimicrobial

Ginger is an effective antiviral, anti-microbial and anti-fungal. However, most of the studies are done in cell-based studies. Additional clinical studies may be necessary to confirm the safety and effectiveness of ginger for the treatment of infectious diseases.

22. Fresh Ginger Inhibits Cold Viruses

Fresh, but not dried, ginger can prevent cold viruses from entering human cells in a cell-based study.

23. Ginger Kills Bad Bacteria

Unheated ethanol extract (tincture) of ginger has anti-bacterial effects against disease-causing bacteria in a cell study, including:
·         Staphylococcus aureas
·         Staphylococcus pneumoniae
·         Haemophilus influenzae
·         Pseudomonas aeroginosa
·         Salmonella typhimurum
·         Escherichia coli
Methanol extracts of ginger effectively inhibits the growth of 19 strains of Helicobacter pylori, including drug-resistant strains, in a cell study.

24. Ginger is an Effective Antifungal

Ginger is an effective antifungal at concentrations below 1 mg/ml
Ginger tincture inhibits growth of Candida albicans.

 

Ginger Risks, Side Effects

·         Ginger seems to have little, or no side-effects but may aggravate acid reflux in some individuals .
·         Ginger may affect blood clots, so it should not be taken at the same time as blood thinner medications.
·         The effects of long-term supplementation of ginger remain to be determined.
·         Ginger contains actives that suppress human cytochrome P450 activity, so it may interact with drugs that are metabolized by cytochrome P450 enzymes .

Ginger effect

·         Ginger lowers blood pressure by blocking voltage-dependent calcium channels.
·         Ginger helps with allergies and inflammation, and protects against oxidative stress by activating the Nrf2 pathway .
·         Ginger suppresses Wnt/β-catenin signaling pathway.
·         Ginger inhibits NF-κB signaling.
·         6-Shogaol inhibits growth and apoptosis, and induces autophagy of non-small cell lung cancer by directly regulating Akt1/2 and mTOR pathways.
·         Ethanol extract of ginger activates AMPK and inhibits mTOR in pancreatic cancer cells, and stimulates autophagy .
·         Ginger activates the PPARδ pathway .

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