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Staphylococcus epidermidis & (6-HAP)


The researchers found that the chemical, called 6-N-hydroxyaminopurine (6-HAP), hindered the production of DNA, with work in cell cultures revealing that 6-HAP prevents several types of tumour cells from growing and multiplying



Staphylococcus epidermidis is a Gram-positive bacterium, and one of over 40 species belonging to the genus Staphylococcus.  It is part of the normal human flora, typically the skin flora, and less commonly the mucosal flora
It is an facultative anaerobic bacteria. Although S. epidermidis is not usually pathogenic, patients with compromised immune systems are at risk of developing infection
That type of bacteria commonly found on human skin produces a substance that  help to protect against skin cancer, researchers have revealed.
The scientists say the surprise discovery regarding a strain of Staphylococcus epidermidis highlights the importance of the community microbes found on and in the body in preventing disease.
While it is not clear whether the absence of this strain could increase the risk of skin cancer in individuals, the team say that it is possible the findings might one day lead to preventive treatments for patients.
“The presence of this strain may provide natural protection, or it might be used therapeutically to inhibit the growth of various forms of cancer,” said Prof Richard Gallo, a co-author of the research from the University of California, San Diego.
The finding was somewhat serendipitous. With previous research showing that chemicals produced by Staphylococcus species commonly found on healthy human skin can kill off certain harmful bacteria, the team looked at numerous strains to explore their antimicrobial powers.
Writing in the journal Science Advances, Gallo and colleagues describe how among their results, they discovered a strain of Staphylococcus epidermidis which produced a substance that killed off a type harmful bacteria responsible for infections such as strep throat. While it was not the only strain to do so, the chemical these microbes produced was unusual, boasting a structure similar to one of the key components of DNA, called adenine.
“The strain was originally detected in a screen for antimicrobial activity, but when we identified the nature of the chemical produced by this strain we proceeded with experiments to determine if it might have activity against tumours,” said Gallo.
The researchers found that the chemical, called 6-N-hydroxyaminopurine (6-HAP), hindered the production of DNA, with work in cell cultures revealing that 6-HAP prevents several types of tumour cells from growing and multiplying.
By injecting mice with this substance, the team found that 6-HAP is not toxic. However, when melanoma cells were introduced to mice, animals which had received 6-HAP intravenously ended up with tumours that were more than 60% smaller than those that had not received the substance.
Bacteria 6-HAP is not currently found in any Food and Drug Administration approved drug, according to the FDA’s database.

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